Covers glucagon-like peptide-2’s trophic effects on intestinal mucosa, the GLP-2 receptor, teduglutide as an approved analog, and research into short bowel syndrome and gut barrier integrity.
Category Archives: Peptides
Explores thymulin’s unique zinc-dependent structure, its secretion by thymic epithelial cells, research into T-cell maturation, immune modulation, and the thymulin-zinc-neuroendocrine axis.
Covers the chemistry of hydrocarbon stapling and macrocyclic constraints, how these modifications improve alpha-helical stability, protease resistance, and membrane permeability in peptide drug design.
Explains how CPPs like TAT, penetratin, and polyarginine cross cell membranes, their applications in delivering cargo molecules to intracellular targets, and recent advances in CPP-drug conjugates.
Explores CGRP as one of the most potent vasodilator peptides, its central role in migraine neurobiology, the development of anti-CGRP monoclonal antibodies, and trigeminal pathway research.
Examines pemvidutide’s dual receptor pharmacology targeting both GLP-1 and glucagon receptors, its differentiated liver-targeting profile for MASH/NASH research, and Phase 2 metabolic data.
Covers orforglipron’s unique small-molecule structure that mimics peptide GLP-1 agonism without injection, Phase 3 trial data on metabolic endpoints, and what this means for oral incretin research.
Deep dive into follistatin’s role as a myostatin inhibitor, covering the activin-binding mechanism, animal model data on muscle hypertrophy, and comparisons between FS-288, FS-300, and FS-344 isoforms.
Chemical modifications such as PEGylation, lipidation, and albumin-binding can dramatically extend peptide half-life from minutes to days. This article covers the science behind these modifications and their research implications.
Gonadorelin is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone. It serves as a fundamental research tool for assessing pituitary responsiveness and HPG axis function in laboratory models.