Survodutide 10mg

Buy Survodutide at Loti Labs

Research into metabolic disorders has found compounds that target multiple pathways at once. Survodutide is a big deal in this space as a dual receptor agonist with robust anti obesity efficacy in preclinical studies. This synthetic peptide has caught the attention of researchers studying obesity and metabolic health due to its unique mechanism of action and improved stability.

When researchers want to buy survodutide for their lab work, understanding its molecular properties and research applications is key. The compound’s design addresses the limitations of natural peptides while offering extended half life for research protocols. Our website has all the information you need for this research compound to support your scientific discovery and experimentation.

Molecular Structure of Survodutide

The molecular structure of survodutide reflects sophisticated peptide engineering to overcome the stability issues of metabolic research compounds. This 29-amino-acid acylated peptide has a C18 fatty acid chain that gives it remarkable proteolytic resistance and extended residence time in research models.

Key Molecular Specifications:

The modifications include C-terminal amidation and Ac4c (amino cyclobutyric acid) substitution at position 2 which research shows gives it high resistance to enzymatic degradation. This careful design allows the compound to stay intact in research environments where other peptides would degrade quickly.

The C18 fatty acid chain allows for reversible albumin binding which research shows extends the half life to around 109-115 hours in preclinical models. This extended stability makes survodutide very useful for researchers doing longer term studies on metabolic pathways.

Mechanism of Action

Survodutide (BI 456906) is a potent dual agonist of the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor (GLP-1R). Research shows it has an EC50 of 0.52 nM for GCGR and 0.33 nM for GLP-1R.The dual receptor activation produces different physiological responses that have been documented in lab studies. GLP-1 receptor activation primarily affects satiety pathways and food intake regulation through central nervous system mechanisms. Glucagon receptor activation increases energy expenditure through hepatic glucose production and thermogenic processes.

Research shows this dual mechanism has advantages over single receptor agonists in lab models. Studies comparing survodutide to semaglutide (a selective GLP-1 agonist) in diet induced obese mice showed better weight reduction at maximally effective concentrations. The extra efficacy seems to come from the energy expenditure component of glucagon receptor activation.

Importantly, research shows glucagon receptor activation by survodutide does not produce significant hyperglycemia in experimental models likely due to the balancing effect of simultaneous GLP-1 receptor engagement. This balanced pharmacological profile is a carefully engineered approach to metabolic pathway modulation.

The compound works through multiple metabolic pathways:

• Appetite regulation: Through central GLP-1 pathways affecting food intake
• Energy metabolism: Via glucagon mediated increase in energy expenditure
• Glucose homeostasis: Through balanced receptor activation
• Fat oxidation: Enhanced metabolic efficiency in research models

Research Studies

Preclinical studies have generated a lot of data on survodutide’s pharmacology and biology. Research shows it reduces body weight and plasma glucagon levels in a dose dependent manner across multiple animal models.

Pharmacokinetic studies show impressive residence times to support the compound’s research use. In lab mice, survodutide has a 44 hour residence time, in canine models 140 hours. This is due to the compound’s albumin binding properties and enhanced metabolic stability.

Research shows survodutide’s weight management effects come from both reducing food intake and increasing energy expenditure, just like its receptor targets. Studies have shown enhanced fat oxidation and satiety responses in experimental models, giving researchers multiple endpoints to measure.

Key Research Findings:

• Dose dependent body weight reduction in lab models
• Enhanced satiety responses through central nervous system pathways
• Increased fat oxidation contributing to energy balance
• Sustained pharmacological activity over long periods
• Better efficacy than single receptor agonists in comparable studiesCardiovascular monitoring in research models showed modest heart rate increases (2.3-7.3 bpm mean increase) without arrhythmias or adverse cardiovascular events in the study populations. This safety profile allows for continued research use and experimental protocols.

Current Phase 3 clinical trials are ongoing to investigate the compound, with studies looking at cardiovascular outcomes and long term effects in human subjects. These will provide more data to support research use and scientific understanding.

Storage and Handling

Proper storage and handling is crucial to maintain survodutide’s integrity and research quality. Loti Labs supplies this compound as a freeze-dried lyophilized powder under vacuum seal to protect against degradation and ensure optimal stability for lab use.

Storage Requirements:

• Format: Freeze-dried lyophilized powder
• Environment: Vacuum-sealed containers for stability
• Temperature: Cold chain storage recommended
• Handling: Follow supplier specifications for reconstitution

Solubility characteristics make survodutide versatile for various research applications. It is highly soluble in DMSO up to 100 mg/ml for stock solution preparation. In phosphate-buffered saline (PBS) at pH 7.2, survodutide is soluble up to 10 mg/ml.

Reconstitution should follow supplier’s instructions to ensure compound integrity. Researchers should use appropriate solvents and cold chain storage conditions throughout the preparation and storage process. Proper handling prevents degradation that can compromise experimental results and research quality.

Important Safety Information:

• Research Use Only: This compound is for laboratory research only
• Not for Human Use: Not for diagnostic or therapeutic use
• Lab Protocols: Follow institutional safety guidelines for peptide handling
• Quality Control: Verify purity and identity before use in experiments

The compound has stability for extended research projects when stored properly. However, researchers should verify each batch through appropriate analytical methods before starting experiments.

Why Buy from Loti Labs

Loti Labs provides survodutide in high purity freeze-dried format with verified potency and complete documentation. Our product meets research standards for obesity and metabolic disorder research.

Quality Features:

• High Purity: Tested through third party protocols
• Detailed Documentation: Molecular and handling information
• Competitive Pricing: Cost effective compared to other suppliers* Research Focus: For laboratory use only

Our stock is quality controlled through batch testing and proper storage conditions. Each product is fully analyzed for identity, purity and potency before shipping. This quality control process ensures researchers get compounds that meet their experimental requirements.

The freeze-dried format has stability advantages for research use. This preparation method preserves the compound during storage and shipping while maintaining reconstitution properties for various experimental protocols. Researchers can add to cart with confidence in product quality and consistency.

Research Applications:

• Metabolic pathway studies
• Obesity mechanism research
• Dual receptor agonist studies
• Pharmacokinetic studies
• Comparative efficacy research

We understand the importance of reliable research compounds for scientific discovery. We provide product information and technical support so researchers can use survodutide in their experimental protocols.

Loti Labs Products are for Research Use Only

All products sold by Loti Labs are research chemicals only. This designation allows use of these compounds for in-vitro laboratory testing and experimentation only. Human or veterinary use is strictly forbidden. These products are not for food or cosmetic use and may not be misbranded, mislabeled or misused as such.

The research use only classification ensures compliance with regulations while supporting legitimate scientific research. Researchers must understand these compounds are not approved for any therapeutic use and should only be used in controlled laboratory environments by qualified personnel.

Our research compliance protects our customers and the scientific community. We provide detailed labeling and documentation to ensure proper use and handling of all research compounds. This supports scientific research and regulatory compliance.

Shipping of Loti Labs

Loti Labs ships same day for orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or weekends will ship the next business day. Our shipping process ensures researchers get compounds quickly to support their experimental timelines.

We package compounds to protect integrity during transit. We use appropriate shipping containers and temperature control to maintain product quality from our facility to your laboratory. This attention to shipping details ensures researchers get compounds in optimal condition for research use.

Tracking information is provided for all shipments so researchers can track their orders and plan their experimental schedules. Our shipping partners are chosen for their reliability and ability to maintain proper handling conditions during the delivery process.

Guarantee

Loti Labs offers 30 day money back guarantee on all products. Simply return any unopened products to us for full refund of the purchase price of the unused products. This guarantee shows our confidence in product quality and commitment to researcher satisfaction.

Our return policy recognizes that research requirements can change and product quality is key to successful experimentation. We make the return process easy to minimize disruption to research and ensure customer satisfaction.

To initiate a return, please contact our customer service team via email or through our website. We will provide clear instructions and support throughout the return process so customers can resolve any product issues.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs is tested by third party using HPLC to ensure product purity and accuracy. We provide certificates of analysis for identity, purity and potency of survodutide and all other research compounds.

This comprehensive testing ensures researchers get products that meet their experimental requirements. Our testing protocol checks multiple quality parameters including molecular identity, purity levels and stability characteristics. These analyses support reproducible research results and scientific confidence.

Certificates of analysis are available to review before purchase so researchers can verify our products meet their specific requirements. This transparency supports informed purchasing decisions and helps researchers choose the right compounds for their studies.

Testing Parameters:

• Identity Verification: Molecular structure confirmation
• Purity Analysis: Quantitative purity assessment
• Potency Testing: Activity level verification
• Stability Assessment: Storage condition validation
• Contaminant Screening: Detection of impurities

We partner with accredited laboratories to ensure all analyses meet industry standards for research compounds. This rigorous approach to quality control sets us apart and supports the kind of research that advances scientific knowledge.

Summary

Survodutide is a new metabolic research compound offering researchers a powerful tool to study dual receptor pathways and obesity mechanisms. Its unique molecular design combining stability with dual agonist activity makes it ideal for appetite regulation and energy expenditure studies.

When researchers buy survodutide from Loti Labs, they get high quality compounds backed by testing and documentation. Our research compliance, quality assurance and customer satisfaction guarantee that scientists get the reliable materials they need for their research.The data from preclinical models and pharmacokinetic profile makes survodutide a research tool for metabolic studies. As phase 3 clinical trials provide more data, researchers can use this compound to answer fundamental questions about metabolic regulation and therapeutic target validation.

Ready to add survodutide to your research protocol? Simply click to add to cart and start exploring in your lab. Our team is here to support your research with quality compounds and service.

The future of metabolic research depends on access to advanced compounds like survodutide that can uncover new biology in complex pathways. By choosing Loti Labs as your supplier, you are part of a community of researchers committed to scientific discovery through experimentation and high quality research materials.

References

1. Zimmermann, T., et al. “BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy.” Molecular Metabolism, vol. 66, Dec. 2022, 101633.
2. MedChemExpress. “Survodutide (BI 456906) | GCGR/GLP-1R Agonist.” https://www.medchemexpress.com/survodutide.html
3. Modern Peptides. “Survodutide.” https://modernpeptides.com/product/survodutide/
4. BioSynth. “Survodutide acetate | 2805997-46-8.” https://www.biosynth.com/p/PS00010/2805997-46-8-survodutide
5. Cayman Chemical. “Survodutide (CAS 2805997-46-8).” https://www.caymanchem.com/product/40972/survodutide