Letrozole 2.5mg/ml (30ml)

Buy Letrozole at Loti Labs: Research Compounds

Research into aromatase inhibitors is continually expanding our understanding of hormonal pathways and their applications in various therapeutic areas. Letrozole, a third generation nonsteroidal aromatase inhibitor, is a key compound for researchers studying hormone dependent processes. If you want to buy letrozole for research purposes you need to understand its molecular properties, mechanism of action and sourcing requirements to ensure quality and compliance.

Molecular Structure of Letrozole

Understanding the molecular structure of letrozole gives you insight into its research applications and interaction mechanisms.

Chemical Name: 4,4’-(1H-1,2,4-triazol-1-ylmethylene)dibenzonitrile

Molecular Formula: C17H11N5

Molecular Weight: 285.3 g/mol

PubChem CID: 3902

CAS Number: 112809-51-5

The compound has two benzonitrile groups linked by a triazole moiety which defines its specificity and binding to the aromatase enzyme. This triazole containing structure allows letrozole to bind and inhibit aromatase making it valuable for research into estrogen biosynthesis pathways. Researchers studying hormonal mechanisms find this precise molecular structure essential to understand how certain types of compounds interact with enzymatic processes in the body.

Mechanism of Action

Letrozole is a nonsteroidal aromatase inhibitor in research. The aromatase enzyme converts androgens (androstenedione and testosterone) to estrogens. In postmenopausal women estrogen synthesis occurs mainly in peripheral tissues such as adipose, muscle and skin through this enzymatic pathway.

Research shows that by inhibiting the aromatase enzyme letrozole reduces estrogen levels in experimental models. This mechanism is particularly useful in studies of hormone receptor positive breast cancer where estrogen is a growth factor for malignant cells. Laboratory research demonstrates that letrozole’s inhibition of estrogen synthesis slows down estrogen dependent tumor growth.

Research Studies and Clinical Applications

Numerous large scale clinical trials have proven letrozole’s efficacy in research. Studies show its effectiveness as adjuvant therapy after surgery, extended adjuvant therapy after tamoxifen and as first line therapy for advanced hormone dependent conditions.

Research Application

Research shows that letrozole is effective across various research protocols. The most commonly studied and prescribed letrozole formulation is 2.5 mg once daily. Treatment duration in research is 5 years for adjuvant studies and indefinite for advanced research depending on study parameters and progression markers.

Scientists note that letrozole has linear pharmacokinetics with a half-life of 2 days, making once daily dosing suitable for research protocols. Peak plasma concentrations are reached within 1-2 hours after administration, making it ideal for controlled research environments where timing is critical.

Storage and Safety Considerations

Proper storage of letrozole ensures compound integrity and research validity. Store at room temperature away from moisture and heat. Adhere to storage guidelines to preserve potency and efficacy throughout the research period.

Research shows that letrozole’s effects profile is related to estrogen depletion mechanisms. Common observations in research subjects are hot flashes, muscle pain, joint discomfort and headache. Some studies report increased cholesterol levels and mild gastrointestinal responses in research populations.

More serious observations though less common in research are allergic reactions, thrombotic events, cardiovascular responses like chest pain and hypertension, and hepatic changes. Researchers must note that letrozole is risky and should not be used in pregnant subjects, nursing mothers or premenopausal women due to harm and bone mineral density effects.

Research protocols include careful monitoring of bone health and cardiovascular risk factors during extended studies. Researchers conducting long term research emphasize the importance of regular health assessments to ensure participant safety and data integrity.

Research Use Only Disclaimer

All products sold by Loti Labs including letrozole are for research use only. These products are not for human or veterinary use, diagnostic or clinical use. Loti Labs sells these products to support scientific research, laboratory research and experimental studies.

Researchers and institutions purchasing from Loti Labs must comply with all applicable laws and regulations governing the use of research chemicals. It is the buyer’s responsibility to use these products only in authorized research settings and not to use them for any unauthorized purpose.

This research use only policy reflects Loti Labs commitment to ethical standards and regulatory compliance so our products contribute to scientific advancement without compromising safety or legal requirements.

Shipping of Loti Labs

Loti Labs ships same day for orders placed before 1 PM EST Monday through Friday. Orders placed after 1 PM EST or on weekends will ship the next business day to meet research timelines.

Standard shipping takes 2-3 business days via USPS First Class Mail and expedited shipping options are available for additional fee if research requires faster delivery. Our shipping team ensures all packages are sealed and labeled to maintain compound integrity during transit.

Research facilities can track their orders through our website to see delivery timeline for better research planning. We understand research schedules have critical timing requirements and our shipping policy is designed to support that.

30 Day Money Back Guarantee

Loti Labs offers 30 day money back guarantee on all products. Research institutions can return any unopened products for full refund of the purchase price of the unused compounds. Prescription must remain valid throughout the return process to ensure compliance.

This guarantee gives research facilities confidence in their purchase and helps ensure budget constraints don’t prevent access to quality products. The return policy recognizes research needs can change and we want to support institutional flexibility while maintaining regulatory compliance.

To initiate a return, research coordinators should contact our support team with order details and return information. We will process the file as quickly as possible to minimize impact on research budget or timeline.

Third-Party Tested Every Batch

Every batch of letrozole sold by Loti Labs is third-party tested using High-Performance Liquid Chromatography (HPLC) to ensure product purity and accuracy. Our products meet or exceed FDA standards for potency and purity so researchers can trust their experimental results.

The testing process has multiple quality control checkpoints with detailed documentation for each batch. Research institutions get certificates of analysis that can be included in their research documentation and regulatory submissions.

This quality assurance helps researchers know their experimental results are based on consistent high quality compounds. The third-party testing eliminates batch-to-batch variation that could affect research outcomes or reproducibility.

Letrozole vs Other Compounds

Letrozole is a third generation aromatase inhibitor like anastrozole and exemestane. Research studies show all three are effective with different response profiles and tolerability. Research suggests letrozole may have slightly higher rate of musculoskeletal observations while exemestane, a steroidal inhibitor, may have different effect on bone health parameters.

When researchers compare letrozole to tamoxifen in experimental settings, studies show better outcomes for many research applications especially when tamoxifen resistance or intolerance is observed. The choice between compounds often depends on research objectives and study population.

Researchers doing comparative research should remember each compound has different pharmacological properties that can affect experimental outcomes. Careful consideration of these differences ensures research protocols are optimized for their specific objectives.

Regulatory Compliance and Quality Assurance

Buying letrozole from Loti Labs ensures compliance with all regulatory requirements for controlled distribution for research use. Our prescription verification process involves licensed healthcare providers and maintains documentation required for regulatory oversight.

Research institutions must ensure their use of letrozole complies with their institutional policies and regulatory requirements. This includes proper storage, handling and documentation procedures that support research integrity and regulatory compliance.

Quality control extends beyond third-party testing to include proper packaging, labeling and distribution procedures that maintain compound integrity from our facility to your research location. These procedures ensure research results are based on compounds that meet specified quality standards.

Bottom Line

When researchers need to buy letrozole for research use Loti Labs has a complete solution that combines quality assurance, regulatory compliance and cost effectiveness. Our third-party testing ensures researchers get compounds that meet the highest purity and potency standards and our prescription verification process maintains compliance with all regulatory requirements.

Competitive pricing, reliable shipping and comprehensive support makes Loti Labs the go-to choice for research institutions looking for quality letrozole compounds. Our 30 day money back guarantee and responsive customer support team gives research coordinators confidence when managing complex procurement requirements.

Research institutions ready to order letrozole or want more information about our research compounds contact us to discuss your specific needs and ensure your research protocols have access to the best compounds available.

References

1. Novartis Pharmaceuticals Corporation. Femara (letrozole) prescribing information. Available at: https://www.novartis.com
2. National Cancer Institute. Letrozole. Cancer Drug Information. Available at: https://www.cancer.gov/about-cancer/treatment/drugs/letrozole
3. Loti Labs. Buy Letrozole: Research Compounds. Available at: https://stg.lotilabs.com
4. American Cancer Society. Hormonal Therapy for Breast Cancer. Available at: https://www.cancer.org/cancer/breast-cancer/treatment/hormonal-therapy.html
5. PubChem. Letrozole Compound Summary. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Letrozole
6. ClinicalTrials.gov. Studies on Letrozole in Breast Cancer. Available at: https://clinicaltrials.gov/ct2/results?cond=breast+cancer&term=letrozole
7. U.S. Food and Drug Administration (FDA). Generic Drugs: Questions & Answers. Available at: https://www.fda.gov/drugs/generic-drugs/questions-answers-generic-drugs
8. Mayo Clinic. Letrozole (Oral Route). Available at: https://www.mayoclinic.org/drugs-supplements/letrozole-oral-route/description/drg-20066956

For more information on Letrozole please visit Wikipedia.