GW0742 Capsules (10mg/capsule, 30 capsules)

Buy GW0742 Capsules: PPARδ Research Chemical

Research into selective peroxisome proliferator-activated receptor delta (PPARδ) agonists has exploded in recent years with labs all over the world investigating metabolic pathways and energy homeostasis mechanisms. Among the most potent research chemicals in this category GW0742 stands out as a very selective compound that researchers use to study cellular metabolism, fatty acid oxidation and inflammation pathways in controlled lab settings.

When labs buy GW0742 capsules for their research they need to understand the compound’s molecular properties, research applications and supplier qualifications to ensure experimental integrity and regulatory compliance.

Molecular Structure of GW0742

GW0742 is a research chemical originally developed to study PPARδ receptor mechanisms. The full chemical name is 4-[[2-[[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid, the complex fluorinated structure of which makes it more active than anabolic steroids and other compounds.

Chemical Name: 4-[[2-[[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid

Molecular Formula: C21H17F4NO3S2

Molecular Weight: 471.49 g/mol

PubChem CID: 9893754

CAS #: 317318-84-6

The fluorinated structure makes GW0742 different from other compounds like Cardarine (GW501516) and provides researchers with more selectivity when studying multiple nuclear receptors. Lab tests show that this structure modification allows the compound to interact specifically with PPARδ receptors and show weak activity towards other receptors like androgen receptors, thyroid hormone receptors and vitamin D receptors.

Mechanism of Action

GW0742 is a selective PPARδ agonist with an EC50 of around 1 nanomolar, very potent in research settings. When researchers study this ppar agonist in lab conditions the compound activates downstream genes involved in lipid metabolism and energy homeostasis by binding to PPARδ nuclear receptors.Research shows that GW0742 primary mechanism is to increase fatty acid oxidation in muscle tissue and expression of enzymes involved in lipid breakdown. Lab tests have shown the compound to stimulate AMPK activity and shift cellular preference towards fat as energy source rather than glucose. This metabolic shift supports glucose homeostasis and overall cellular energy use in animal models.

The compound’s activation of PPARδ receptors affects multiple metabolic pathways, researchers have noted its effect on increasing metabolism through enhanced oxidative capacity in different tissues. Clinical research on spontaneously hypertensive rats has shown that GW0742 modulates gene expression related to inflammation and cardiovascular function, more research is needed to fully understand these mechanisms.

Research

Lab tests consistently show GW0742’s effect on metabolic markers across different animal models. In diet induced obese mice, researchers saw increased fat oxidation and improved cellular energy metabolism after treatment. The data shows improved glucose homeostasis and insulin sensitivity in diabetic animal models, supporting research into metabolic disorders.

As a fluorinated analog of Cardarine, GW0742 is more active than GW501516 with structural differences that researchers have shown to affect its selectivity and potency in lab settings. Some lab reports suggest the compound is 150-200 times more potent than GW501516 in fat loss and fat loss mechanisms, but these findings need to be verified in different research protocols.

GW0742 also has anti-inflammatory properties making it useful for studying chronic inflammatory disease models. Labs have used the compound to study cytokine production and oxidative stress in atherosclerosis, lung injury, kidney inflammation and ocular diseases. However researchers need to consider context dependent outcomes of PPARδ activation as some studies have shown the compound to increase angiogenic markers in retinal models.

The compound’s effect on body fat reduction and muscle preservation has made it a subject of research in body composition studies but all applications are strictly in lab settings for research purposes only.

Storage and Safety

Proper storage protocols are important when labs buy GW0742 capsules to maintain compound integrity and experimental reproducibility. The research chemical requires cold chain storage at temperatures between -20°C and 2-8°C for optimal stability. Researchers need to verify that their storage facilities can maintain these conditions consistently to prevent compound degradation.GW0742 is not soluble in water but soluble in organic solvents like DMSO where it can reach concentrations above 5mg/mL for use. Lab protocols typically use nanomolar to low micromolar concentrations (1-100nM) to activate PPARδ selectively and have controls.

Research data shows cell viability above 90% at concentrations below 12.1μM, giving researchers clear guidelines for concentration limits in cell studies. This safety margin allows investigators to study the compound’s effect on metabolism without significant cell death and get reliable results.

When handling GW0742 capsules, lab personnel should follow standard research chemical safety protocols, proper ventilation, personal protective equipment and documentation procedures. The compound’s stability requires temperature control during transport and storage to maintain experimental consistency.

Why Buy from Loti Labs

Loti Labs offers GW0742 capsules in convenient formulations for research use. We provide multiple concentration options 10mg, 20mg, 25mg and 50mg capsules so researchers can choose the right amount for their experiment without waste or excess.

We maintain high purity standards, our products are 98-99.99% pure verified through third party testing. This high purity ensures researchers can get consistent results across experiments and minimize variables introduced by impurities or contaminants. Each batch is analyzed to verify compound identity, concentration and stability.

We provide complete documentation to support research reproducibility and regulatory compliance. Researchers get certificate of analysis, batch tracking information and testing data to support their experimental validation requirements. This documentation is essential for labs maintaining quality assurance protocols and regulatory guidelines.

Our customer service extends beyond product quality to technical support and consultation services. Researchers can get guidance on storage protocols, concentration preparation and experimental design considerations to get successful results.

Products from Loti Labs are for Research Use Only

All products sold by Loti Labs, including GW0742 capsules are research chemicals for lab use only. This designation allows the use of these compounds only for in-vitro lab testing and experimentation under controlled conditions. Human or veterinary use is strictly forbidden under all circumstances.These products are not for human consumption and should not be misbranded, mislabeled or misused outside of their designated research applications. Laboratories must keep proper documentation and protocols to ensure research only guidelines when purchasing and using these compounds.

Researchers and institutions must verify their qualifications and intended use before placing any order. Since these compounds are not approved for human therapeutic use, all research must stay within approved research framework, with proper oversight and documentation throughout the research cycle.

Shipping Policy of Loti Labs

Loti Labs ships same day for orders placed before 1pm EST Monday to Friday, so researchers can meet their experimental timelines. Orders placed after 1pm EST or on weekends will be shipped the next business day for predictable scheduling.

We offer free international shipping for qualifying orders so researchers can get high quality research chemicals worldwide. This global reach supports collaborative research while maintaining the same quality standards and documentation requirements everywhere.

Proper packaging ensures compound integrity during transport, temperature controlled shipping is available for compounds that require specific storage conditions. Researchers can track their orders and get confirmation when the shipment is completed, for inventory management and experimental scheduling.

Money Back Guarantee

Loti Labs stands behind their product quality with a 30 day money back guarantee for all research chemicals. Researchers can return any unopened product within this timeframe for a full refund of the purchase price, we are confident in our quality control process.

This guarantee gives labs the confidence to try new compounds for research, knowing they can return unsatisfactory products without financial loss. It supports research institutions to explore new experimental directions with minimal financial risk.

The guarantee applies to unopened products in their original packaging, so returned products are in the same condition for potential redistribution. Researchers should contact customer service to initiate returns and get authorization before shipping products back to us.

Third Party Testing of Every Batch

Every batch of GW0742 capsules is tested by third party using high performance liquid chromatography (HPLC) to ensure product purity and accuracy. This independent verification confirms compound identity, concentration and stability for reproducible results across different labs and experimental conditions.

The testing protocol checks multiple parameters including chemical composition, impurity levels and concentration accuracy. The results are documented in the certificate of analysis that researchers receive with their order, for experimental validation and regulatory compliance.Our quality control goes beyond basic purity testing to include stability analysis and contamination screening. This ensures researchers get compounds suitable for sensitive applications whether it’s cellular metabolism, receptor binding or other research applications.

The third party verification process supports scientific integrity by providing independent confirmation of product specifications. Researchers can reference these testing results in their publications and grant applications to support their data and conclusions.

Conclusion

When laboratories want to buy GW0742 capsules for PPARδ research and metabolic pathway investigation, choosing a reputable supplier with proven quality standards is crucial. The compound’s potency and complex molecular structure requires special handling and storage protocols only experienced research chemical suppliers can provide.

GW0742’s unique properties as a selective PPARδ agonist makes it a valuable tool for investigating fatty acid oxidation, glucose homeostasis and inflammation pathways in controlled lab environment. Its higher potency than other related compounds allows researchers to investigate metabolic mechanisms with higher precision and reproducibility.

For researchers ready to expand their PPARδ agonists and metabolic research, Loti Labs is the best place to buy high quality GW0742 capsules with documentation and support. We guarantee purity, testing and compliance so researchers can focus on their scientific goals while maintaining the highest experimental integrity.

References

1. Wang, Y.X. (2010). PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Research, 20(2), 124-137. https://doi.org/10.1038/cr.2010.13
2. Oliver, W.R. Jr., et al. (2001). A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proceedings of the National Academy of Sciences, 98(9), 5306-5311. https://doi.org/10.1073/pnas.091127198
3. Narkar, V.A., et al. (2008). AMPK and PPARδ agonists are exercise mimetics. Cell, 134(3), 405-415. https://doi.org/10.1016/j.cell.2008.06.0514. Lee, C.H., et al. (2006). PPARδ regulates glucose metabolism and insulin sensitivity. Proceedings of the National Academy of Sciences, 103(9), 3444-3449. https://doi.org/10.1073/pnas.0511079103
4. Barish, G.D., et al. (2006). PPARδ regulates multiple proinflammatory pathways to suppress atherosclerosis. Proceedings of the National Academy of Sciences, 103(38), 14904-14909. https://doi.org/10.1073/pnas.0604259103
5. Wang, Y., et al. (2011). GW0742, a PPARδ agonist, improves insulin sensitivity and reduces inflammation in obese mice. Journal of Pharmacology and Experimental Therapeutics, 337(2), 543-551. https://doi.org/10.1124/jpet.110.176273
6. Lee, C.H., et al. (2008). PPARδ activation ameliorates hypertension and endothelial dysfunction in spontaneously hypertensive rats. Hypertension, 51(6), 1532-1538. https://doi.org/10.1161/HYPERTENSIONAHA.107.104581
7. Loti Labs. (2024). GW0742 capsules product information and quality assurance.