Anastrozole 1mg/ml (30ml)

Buy Anastrozole Liquid at Loti Labs

When researching hormone dependent pathways you need precise and reliable compounds that give consistent results across all your protocols. When investigating aromatase inhibition and estrogen synthesis pathways the quality and purity of the research compounds directly impacts the experimental outcomes and data integrity. For scientists investigating these critical biological processes anastrozole liquid is a potent tool for selective enzyme inhibition studies.

The field of hormone research has shown complex interactions between aromatase enzyme activity and various physiological processes. Studies have shown that aromatase inhibitors play key roles in research models of breast cancer progression, advanced breast cancer mechanisms and metastatic breast cancer pathways. These studies require compounds that are stable, potent and give reproducible results across different experimental conditions.

When you want to buy anastrozole liquid for your lab research you need to understand the molecular properties, mechanism of action and handling requirements. The compound’s effectiveness in research applications depends heavily on the formulation quality, storage protocols and the supplier’s quality control measures.

Molecular Structure of Anastrozole

Anastrozole has a specific chemical architecture that enables it to be a selective aromatase inhibitor. The compound’s chemical name 2,2’-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropiononitrile) reflects its triazole containing structure that allows for precise enzyme binding.

The anastrozole chemical structure cas registry number 120511-73-1 is for your reference and regulatory compliance. This molecular structure allows the compound to be specific for the aromatase enzyme and stable in different research formulations.Research applications benefit from the 1mg/mL concentration which allows for accurate dilution calculations using the C1V1 = C2V2 formula. This is important when designing dose response studies or setting up concentration gradients for in vitro anastrozole experiments. The clear solution form allows for uniform distribution and you can mix evenly across your experimental conditions.

Mechanism of Action

Anastrozole liquid is a potent selective aromatase inhibitor with an IC50 of 15 nM against human placental aromatase. Research has shown that the compound is approximately 200 times more potent than aminoglutethimide in laboratory studies so it’s effective in enzyme inhibition experiments.

The compound selectively inhibits human placental aromatase, the enzyme that converts androgens to estrogens in different tissue types. This inhibition results in significant reduction of estradiol synthesis, research has shown 50-60% decrease in estrogen production. The mechanism is competitive binding to the enzyme active site, blocking the conversion pathway that produces estrogen from testosterone and androstenedione.

In research on cancer cells especially those derived from breast tissue anastrozole is effective in models where estrogen dependent growth pathways are being investigated. Clinical trials have used this compound to study hormone receptor positive conditions but laboratory researchers focus on understanding the underlying biochemical mechanisms through controlled experimental systems.

The selectivity becomes important when studying human placental microsomes where aromatase activity plays critical roles in steroid hormone synthesis. Research has shown that anastrozole’s binding affinity and residence time on the enzyme contributes to its sustained inhibitory effects making it useful for studies that require prolonged enzyme suppression.

Studies on male pigtailed monkeys have given insights on the compound’s effect on aromatase activity across different tissue types. These studies have shown tissue specific response to aromatase inhibition and helps in understanding estrogen synthesis regulation in different biological contexts.

Research Studies

Anastrozole liquid research formulations are optimized for laboratory use with specific vehicle composition designed to enhance solubility and biocompatibility. The formulation method varies depending on whether the study is in vitro or in vivo, each requires careful consideration of vehicle effect on experimental outcome.

This simplified composition reduces toxicity concerns while maintaining enough bioavailability for research purpose. The corn oil vehicle allows for absorption and provides a stable matrix for compound delivery in experimental animals.These formulations allow for precise delivery in research models of hormone dependent pathways. Studies on apoptosis in estrogen sensitive cell lines benefit from the controlled release of these formulations. Research on arthritis models has also used anastrozole formulations to study the role of estrogen in inflammatory processes.

The choice of formulation affects compound stability and biological activity so researchers need to choose the right vehicle composition based on their experimental requirements. Some studies may require modification to standard formulations to accommodate specific experimental conditions or analytical methods.

Storage and Safety

Anastrozole liquid requires specific storage conditions to maintain stability and efficacy throughout the research period. Proper handling protocols ensure compound integrity and reproducible results across multiple studies.

Storage Requirements

Do not repeat freeze-thaw cycles that may compromise compound integrity and potency. The solution should be protected from light and moisture unless otherwise specified in experimental protocols. Label storage dates and concentration information to maintain laboratory organization and safety standards.

Research Observations

Safety considerations include observations made in research models during experimental protocols. Studies have shown various physiological responses in animal models including thermoregulatory changes that may affect experimental conditions. Joint symptoms have been noted in some research animals especially in long term studies of chronic aromatase inhibition.

Research models have shown mood changes associated with reduced estrogen synthesis and provide insights into hormone-behavior relationships. Some studies have reported hot flashes in experimental subjects reflecting the compound’s ability to reduce estrogen production.

More significant research observations include effects on bone mineral density in animal models treated for prolonged period. Studies on osteoporosis development have used anastrozole to study the relationship between estrogen deficiency and bone metabolism. Research on fractures and bone strength have given valuable data on hormone-bone interactions.

Studies on heart disease risk factors have examined how aromatase inhibition affects cardiovascular parameters in research models. These studies help understand the complex relationship between hormone status and cardiovascular health.

Monitor experimental subjects for signs of weakness or other physiological changes that may indicate compound effect. Some studies have noted nausea or vomiting in research animals but this varies depending on the experimental protocol and species used.Additional considerations include skin reactions at injection sites in research animals which are usually localized and resolve without intervention. Headache-like behaviors have been seen in some primate studies suggesting central nervous system effect of estrogen suppression.

Why Buy from Loti Labs

Loti Labs offers research grade anastrozole liquid with 1mg/mL concentration for precise dilution using standard laboratory calculations for experimental protocols. The formulation remains stable throughout the research period when stored according to recommended conditions to ensure consistent results across extended study duration.

Quality Control

Each batch undergoes strict quality control to ensure consistency in research applications. The company maintains 99.99% HPLC confirmed purity standards so researchers can have confidence in compound quality and potency. This level of purity is critical for studies where even minor impurities can affect experimental outcome.

Third party testing protocols verify compound identity and purity using high performance liquid chromatography (HPLC), a gold standard analytical method in pharmaceutical research. Certificate of analysis is provided with each shipment, detailing quality parameters and test results.

Delivery and Logistics

Efficient delivery systems support research timelines and experimental scheduling. The company’s logistics network ensures temperature sensitive compounds remain intact during transport, using appropriate packaging and shipping methods for research chemicals.

Researchers can adjust their ordering schedule to fit experimental timelines, with flexible delivery options for both routine laboratory operations and urgent research needs. The supply chain helps prevent experimental delays due to compound availability.

Loti Labs Products are for Research Use Only

All products sold by Loti Labs are research chemicals only. This designation allows use of these compounds strictly for in-vitro laboratory testing and experimentation. Human use is strictly forbidden and these products are not intended for human or veterinary use.

This product is not a prescription substance, food or cosmetic and may not be misbranded, mislabeled or misused as such. The research use only designation ensures compliance with regulatory requirements and prevents misuse.

Researchers must understand that these compounds are intended only for laboratory investigations of biological mechanisms, cellular processes and molecular pathways. Studies involving these compounds must follow established research protocols and institutional safety guidelines.

The distinction between research chemicals and therapeutic agents is critical for regulatory compliance and ethical research practices. Pharmacist consultation or medical supervision is not applicable to research chemical use as these compounds serve different purpose than prescription substances used in clinical settings.

Shipping Policy of Loti Labs

Loti Labs ships same day on orders placed before 1pm EST Monday through Friday. Orders placed after 1pm EST or on weekends will be shipped the next business day. This expedited shipping helps research timelines and prevents experimental delays.

Temperature controlled shipping ensures compound stability during transport, using appropriate packaging materials and delivery methods for research chemicals. Tracking information is provided for real-time updates on shipment status and expected delivery time.

Money Back Guarantee

Loti Labs offers 30 day money back guarantee on all products. Researchers can return any unopened products for full refund of the purchase price. We are confident in our product and customer service.

This guarantee gives researchers flexibility when planning experiments and ordering compounds. It also helps research budget by reducing risk of product quality concerns or changing experimental requirements.

Third Party Testing of Every Batch

Every batch of products sold by Loti Labs is tested by third party using HPLC to ensure product purity and accuracy. Certificate of analysis is provided with each purchase so researchers can proceed with confidence in their experimental protocols.

Independent testing laboratories perform these analyses using validated analytical methods and calibrated instrumentation. The testing protocols verify compound identity and purity to ensure researchers receive materials that meet specifications for their intended use.

Stability testing under various storage conditions is also included to help researchers know how to maintain compound integrity throughout their experimental timeline. These comprehensive testing protocols support reproducible research outcomes and scientific rigor.

Research Applications and Considerations

When researchers buy anastrozole liquid, they get a compound that has been proven to work in many research applications. Studies of hormone dependent cellular processes benefit from the compound’s selectivity and dose response.

Research into breast cancer mechanisms uses anastrozole to study how aromatase inhibition affects tumor cell growth and survival pathways. These studies help understand the complex relationship between hormone synthesis and cellular proliferation in cancer models.

Studies of advanced breast cancer progression use anastrozole to see how prolonged aromatase inhibition affects metastatic processes and cellular invasion. Research models using anastrozole help scientists understand the molecular events underlying disease progression and treatment response.

Research into metastatic breast cancer uses the compound to see how estrogen synthesis affects cellular migration and tissue invasion. These studies provide insights into hormone dependent aspects of cancer biology and potential therapeutic targets.Research into aromatase inhibitors and bone metabolism has shown important links between estrogen synthesis and skeletal health. Studies of osteoporosis development in animal models show how hormone suppression affects bone formation and resorption.

Comparative studies with other compounds like tamoxifen give researchers valuable data on different ways to modulate hormone pathway. These studies help scientists understand the relative effectiveness of different research tools for estrogen dependent processes.

Experimental Considerations

Researchers should consider the following when using anastrozole liquid in their experimental protocols. The compound is potent and requires careful attention to concentration calculations and dose preparation to ensure proper experimental conditions.

Studies of enzyme inhibition kinetics benefit from the compound’s well characterized binding properties and competitive inhibition mechanism. Research into cellular response pathways can use anastrozole’s selectivity to isolate estrogen dependent effects from other hormonal influences.

The compound is stable under various experimental conditions allowing for extended studies of chronic aromatase inhibition. Research protocols can accommodate both acute and chronic exposure models depending on the research question.

Experimental design should account for potential interactions between anastrozole and other research compounds or cellular culture conditions. Some studies may require vehicle controls or comparative analysis with related compounds to isolate specific effects.

Researchers studying postmenopausal women models or age related hormonal changes may find anastrozole useful for studying estrogen synthesis regulation across different life stages. These applications help understand how hormone production changes with aging and disease states.

Conclusion

Research into hormone dependent biological processes requires access to high quality compounds that deliver consistent and reproducible results. When scientists buy anastrozole liquid from Loti Labs they get a research tool that combines molecular precision with quality standards, for multiple experimental applications.

The compound’s mechanism of action, formulation properties and quality control measures make it suitable for studies of aromatase inhibition and estrogen synthesis pathways. From cellular studies to complex animal models anastrozole liquid provides researchers with the reliability they need for scientific progress.

Loti Labs’ commitment to quality, backed by third party testing and extensive scientific validation ensures researchers get compounds that meet the highest purity standards. The company’s research only designation maintains regulatory compliance while supporting legitimate scientific research.

For research teams studying hormone dependent processes, cancer cell biology or endocrine system function anastrozole liquid is a valuable addition to their toolkit. The combination of molecular specificity, formulation stability and quality assurance is the foundation for meaningful science.Look into anastrozole liquid for your next research protocol on aromatase inhibition or estrogen dependent cellular processes. Review the specs, storage and application guidelines to see how this compound can support your research goals.

References

1. Dukes M, et al. The preclinical pharmacology of “Arimidex” (anastrozole; ZD1033)—a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45.
2. Kelly CM, Buzdar AU. Anastrozole. Expert Opin Drug Saf. 2010 Nov;9(6):995-1003.
3. Hong Y, Chen S. Aromatase inhibitors: structural features and biochemical characterization. Ann N Y Acad Sci. 2006 Nov;1089:237-51.
4. McCloskey E. Effects of third-generation aromatase inhibitors on bone. Eur J Cancer. 2006 May;42(8):1044-51.
5. Xanthopoulos JM, Romano AE, Majumdar SK. Response of Mouse Breast Cancer Cells to Anastrozole, Tamoxifen, and the Combination. J Biomed Biotechnol. 2005;2005(1):10-19.
6. Bayview Pharmacy. Anastrozole 1 mg/ml Gastric Tube Liquid – Customized Care. Available at: https://www.bayviewrx.com/formulas/Anastrozole-1-mg-ml-Gastric-Tube-Liquid-Breast-Cancer-Ovarian-Cancer-Endometrial-Cancer-Infertility-McCune-Albright-Syndrome
7. MedChemExpress. Anastrozole (ZD1033) | Aromatase Inhibitor. Available at: https://www.medchemexpress.com/Anastrozole.html

For more information on Anastrozole please visit WikiGenes.