Buy 5-Amino-1MQ Peptide at Loti Labs

Research into metabolic pathways has found several compounds that may help scientists understand cellular energy production and metabolism. Among these investigational substances 5 amino 1mq has turned out to be a very interesting small molecule for lab research. This compound gives researchers the opportunity to study nicotinamide n methyltransferase inhibition and its effects on cellular metabolism in controlled lab settings.

As research continues to uncover the complex relationships between nad levels, mitochondrial function and cellular energy, compounds like amino 1mq are valuable tools to advance our understanding of these fundamental biological processes. Below is a comprehensive overview of the molecular characteristics, research findings and lab applications of this investigational compound.

Molecular Structure of 5-Amino-1MQ

The compound 5 amino 1mq has the chemical name 5-amino-1-methylquinolinium, a small molecule methylquinolinium derivative with amino substitution at position 5. Research has determined its molecular formula to be C10H11N2+ with a molecular weight of 159.21 g/mol. The CAS number 42464-96-0 is the unique identifier for this substance in chemical databases and lab research.

Lab studies have characterized this molecule as a white to off-white crystalline powder with high water solubility. These physical properties make it suitable for various lab applications where cellular penetration and bioavailability are important. The structure allows the compound to cross cell membranes and interact with intracellular targets in research models.

The quinoline ring with methyl and amino group modifications gives researchers a compound that is stable and has specific binding properties. This molecular architecture has proven very useful in enzyme inhibition and cellular metabolism pathway studies.

Mechanism of Action

Research shows that 5 amino 1mq works primarily through selective inhibition of the nicotinamide n methyltransferase (nnmt) enzyme. This enzyme is crucial in cellular metabolism, especially in liver and adipose tissues where nnmt activity affects cellular energy balance and fat metabolism.Research shows that nnmt inhibition by this compound may help preserve and increase intracellular nad levels by reducing nicotinamide adenine dinucleotide consumption. Nad production seems to support various cellular processes including mitochondrial function and energy production at the cellular level.

Research has found that blocking nnmt activity may lead to:

• Activation of sirt1 pathways and mitochondrial biogenesis via PGC-1α
• Increased basal metabolic rate and fatty acid oxidation in research models
• Improved insulin sensitivity and metabolic flexibility in lab studies
• Enhanced cellular energy production and mitochondrial function
• Reduction of 1-methylnicotinamide (1-MNA) in adipose tissue samples

The compound’s effects on these pathways make it a valuable tool for researchers studying metabolic health, cellular metabolism and age related changes in energy levels. Lab research has shown that supporting nad levels can maintain optimal cellular function and support healthy aging in research models.

Research Studies

Scientific research on 5 amino 1mq has produced significant findings on metabolism and cellular function. The landmark study by Kraus et al. (2014) showed impressive results when testing the compound in diet-induced obese mice models.

Research results from this study found that treated subjects lost 5.1% body weight compared to 1.4% gain in control groups. More importantly, researchers observed 35% reduction in epididymal white adipose tissue mass without changing food intake patterns. This suggests that the compound may affect fat storage and fat loss mechanisms independently of caloric consumption.

Additional research outcomes were:

• 30% decrease in plasma cholesterol levels in treated subjects
• Significant reduction in adipocyte size and metabolic parameters
• Improved insulin sensitivity and glucose metabolism
• Improved metabolic markers across multiple parameters

Lab studies using 3T3-L1 adipocyte models showed dose dependent effects on lipogenesis suppression. Researchers found an EC50 of approximately 2.3 µM for nnmt inhibition in differentiated adipocytes. These cellular studies give insight on how the compound works at the cellular level to affect fat metabolism and energy production.

Selectivity testing confirmed that 5 amino 1mq is specific against related methyltransferases including COMT, DNMT1 and PRMT3. This selectivity profile makes it a research tool to study nnmt related pathways without confounding effects from other enzyme targets.Research suggests that nnmt inhibitors may offer new ways to understand metabolic dysfunction and age related changes in cellular energy production. This research provides a foundation to further explore how supporting nad levels and mitochondrial function can benefit overall metabolic health.

Storage and Handling

Proper storage and handling protocols are crucial for compound integrity in research applications. Laboratory studies recommend storing 5 amino 1mq at -20°C for long term storage, stable for up to 2 years. Short term storage at 2-8°C is acceptable for up to 30 days without degradation.

Keep the compound away from light and moisture during storage. Reconstituted solutions are stable for 7 days when stored refrigerated, allowing for multiple uses from a single preparation.

PAMPA and Caco-2 assays have shown high membrane permeability and bioavailability. Cell viability studies have shown no cytotoxicity at ≤100 µM, providing a wide working range for experimental protocols.

Follow safety protocols and handle the compound in a controlled lab environment with personal protective equipment. Follow institutional guidelines for handling research compounds and document usage and storage conditions.

The compound’s stability and safety profile makes it suitable for long term research projects where consistent results and performance are critical. Proper storage and handling ensures reproducible results across multiple experiments and research teams.

Why Buy from Loti Labs

Loti Labs offers pharmaceutical grade 5 amino 1mq with >98% purity verified by HPLC. This level of purity ensures consistent research results and minimizes potential variables that can affect experimental outcomes.

We offer competitive pricing for high quality research compounds while maintaining strict quality control. Every batch is tested for identity, purity and potency.

Benefits of buying from Loti Labs:

• Technical support for research applications and protocol development
• Reliable supply chain for consistent product availability
• Detailed certificates of analysis
• Fast processing and shipping for urgent research needs* Established brand in the research community

The company’s quality control helps researchers trust their results. Each batch is tested for molecular identity, purity and potency before being shipped to research customers.

Technical support helps researchers to optimize protocols and answer application specific questions. This is especially useful for researchers who are using the compound for the first time or developing new protocols.

Loti Labs Products are for Research Use Only

5-Amino-1MQ from Loti Labs is for in-vitro laboratory research and experimentation only. Not for human consumption, therapeutic use or clinical applications. Researchers must understand that this compound is investigational and not FDA approved for any medical indication.

All research applications must comply with institutional guidelines and established safety protocols. The compound cannot be misbranded, mislabeled or misused for non-research purposes under any circumstances. Products are for qualified researchers in academic, pharmaceutical or biotechnology settings with appropriate training and facilities.

Research institutions and individual researchers are responsible for proper use, handling and disposal of the compound according to applicable regulations and institutional policies. Documentation of research use and maintenance of records is essential for regulatory compliance and research integrity.

The research only designation reflects the current status of the research on this compound. While research suggests promising applications for cellular metabolism and energy production, this is still in the experimental stage and more research is needed before any broader applications can be considered.

Loti Labs Shipping Policy

Loti Labs ships same day for orders placed before 1pm EST Monday through Friday, so researchers can get compounds quickly for time sensitive experiments. Orders placed after 1pm EST or on weekends ship the next business day to maintain service levels.

Temperature controlled shipping is available for stability sensitive compounds to ensure researchers receive products in optimal condition. Expedited shipping is available for urgent research needs when standard shipping won’t meet project deadlines.

The company’s shipping protocol includes proper packaging and labeling to maintain compound integrity during transport. Tracking information is provided for all shipments so researchers can track the delivery and plan for receipt and storage.

30 Day Money Back Guarantee

Loti Labs stands behind product quality with a 30 day money back guarantee on all 5 amino 1mq purchases. Researchers can return unopened products within the guarantee period for a full refund if the compound doesn’t meet their research requirements. If quality issues arise, we will replace or refund as appropriate. Customer service will help with product related questions and resolve any issues that may come up during research.

This guarantee shows our confidence in our product and commitment to your research success. It gives you peace of mind when investing in compounds for critical research.

Third Party Testing of Every Batch

Every batch of 5 amino 1mq is HPLC tested for purity and identity before shipping. Mass spectrometry is used to verify molecular structure and composition so you get exactly what you need for your experiments.

Testing includes:

• Endotoxin testing to ensure low bacterial contamination
• Heavy metals analysis to verify no toxic contaminants
• Residual solvent testing to confirm purity standards
• Certificate of analysis with test results and specifications

This level of testing gives you confidence in compound quality and consistency. The COA provides transparency on testing methods and results to support your research documentation and regulatory compliance.

Third party testing verification adds an extra layer of quality assurance beyond our internal quality control. It ensures the testing results are objective and reliable for research use.

References

1. Kraus, D. et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature Medicine, 20(8), 1029–1038. https://doi.org/10.1038/nm.3645
2. Kannt, A., & Pfenninger, A. (2017). Novel nicotinamide N-methyltransferase inhibitors as potential therapeutics for obesity. Frontiers in Physiology, 8, 123. https://doi.org/10.3389/fphys.2017.00123
3. Price, N. L. et al. (2012). SIRT1 is required for AMPK activation and the metabolic effects of resveratrol. Cell Metabolism, 15(5), 675–690. https://doi.org/10.1016/j.cmet.2012.04.003
4. Cantó, C. et al. (2009). AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature, 458(7241), 1056–1060. https://doi.org/10.1038/nature078135. [Author(s)]. (2017). Nicotinamide N-methyltransferase inhibitors reverse high fat diet-induced obesity in mice. Biochemical Pharmacology, 147, 141–152. https://doi.org/10.1016/j.bcp.2017.11.007

Contact Loti Labs for more information and 5 amino 1mq research compounds.